Postpartum Depression: Causes, Symptoms, and Treatment | Everyday Health


postpartum depression articles

Aug 23,  · Postpartum depression (PPD) affects one out of every eight women in the U.S. Read about postpartum depression symptoms, treatment, and causes. Statistics indicate that PPD can affect as many as 10% of new fathers, as well. Dec 08,  · Postpartum depression is a mental health condition that can occur after giving birth to a child. Learn why it happens and how to treat it. Jun 22,  · Your articles about postpartum depression are a comprehensive, accurate account of the various ways that perinatal illnesses can present. Postpartum .

Post‐partum depression: a comprehensive approach to evaluation and treatment

The first drug for postpartum depression articles suffering postpartum depression received federal approval on Tuesdaya move likely to pave the way for a wave of treatments to address a debilitating condition that is the most common complication of pregnancy.

The drug works very quickly, within 48 hours — a significant improvement over currently available antidepressants, which can take two to four weeks to have an effect, if they work at all. Experts say the new treatment will provide immediate relief for mothers whose depression keeps them from providing their babies with the care, bonding and nurturing that is crucial for healthy development.

As many as one in seven American women experience depression during or after pregnancy. Sign up for the Science Times newsletter. There are limitations to the new drug, brexanolone, which will be marketed as Zulresso. It is delivered by infusion over 60 hours, during postpartum depression articles a new mother must remain in a certified medical center, under supervision should she get dizzy or faint, as several patients did in clinical trials.

That does not include the costs of postpartum depression articles in a medical center for two and a half days. Company officials say they expect that insurers will cover the treatment; insurers said this week that they are evaluating the drug, postpartum depression articles.

A pill made with a similar molecule, which would be much more accessible and easier for patients, is showing promise in its clinical trials and would be submitted for approval in a couple of years if the results are good, according to Sage.

The infusion is to be administered just once, postpartum depression articles, and patients may also take standard antidepressants. Clinical trials of the drug, all sponsored by Sage, found that it produced a steeper decrease in symptoms in women with severe and moderate postpartum depression than a similar placebo infusion.

The relief from depression continued for a month after the treatment. While there were anecdotal reports that it extended beyond that period for some women, there has not been systematic research on longer-term results. Margaret Spinelli, a clinical postpartum depression articles of psychiatry at Columbia University, who treats postpartum depression articles studies postpartum depression and was not involved in the research on brexanolone.

The treatment may be helpful for up postpartum depression articles 30 percent of theAmerican women who develop postpartum depression each year, said Dr.

Kimberly Yonkers, postpartum depression articles, a professor of psychiatry, obstetrics, gynecology and reproductive sciences at Yale, postpartum depression articles, who was not involved in the research. Candidates for treatment would likely be those experiencing severe symptoms or who failed to improve on standard antidepressants, said Dr.

Yonkers, who was not involved in the research. Yonkers said. Stephanie Hathaway, 33, a mother of two in South Windsor, Conn.

But after giving birth to her daughters — Hadley, 4, and Brenley, 2 — she began crying nonstop, and lost interest in doing things she loved, like cooking and socializing.

Ultimately Ms. Hathaway felt suicidal and feared she would harm herself if she stopped holding the baby. Hathaway, then living with her husband in China, spent two postpartum depression articles under round-the-clock suicide watch at home. The antidepressant she was prescribed, Zoloft, took three months, at increasing dosages, to eliminate her symptoms. Hathaway said, so about five months afterward, she volunteered for the brexanolone trial.

Hathaway said. She did not stop antidepressants altogether, but switched to a low dose of Effexor. Dizziness and sleepiness were the most common side effects in the trials, each affecting about one in eight patients, including Ms. The most worrisome effect, the F. All recovered within an hour and resumed getting the infusion.

Brexanolone is a synthetic form of allopregnanolone, a hormone produced by progesterone in the brain that may help ease depression and anxiety by dampening neural activity, said Dr. Samantha Meltzer-Brody, director of the perinatal psychiatry program at the University of North Carolina at Chapel Hill, who was the principal investigator for the brexanolone studies.

The research presented to the F. Meltzer-Brody and funded by Sage Therapeutics, which was also involved in the study design, data analysis, interpretation and writing of the reports, postpartum depression articles. The trials involved women randomly selected to receive a placebo or brexanolone — a relatively small number of participants, compared to many other medical trials.

Still, postpartum depression articles, the results were considered persuasive by a joint F. The women in postpartum depression articles trials had given birth within six months of getting the infusion and were experiencing severe or moderate depression that had started in the third trimester of pregnancy or within four weeks after childbirth.

Participants could not have psychosis or bipolar disorder. Their symptoms could include suicidal thoughts but not a recent suicide attempt. They were asked to stop breast-feeding during the infusion and for a postpartum depression articles days after. But Dr. Meltzer-Brody said the drug appears safe for nursing mothers and babies, because very little of it seeps into breast milk.

Depression improved in the women receiving brexanolone and in those receiving placebo, a phenomenon common in studies of depression treatments. But more women in the brexanolone group showed improvement, and their improvement was more substantial, postpartum depression articles. In one trial, severely depressed women started with scores of about 28 out of 30 on the Hamilton Depression Scale, a standard evaluation tool. After the infusions, postpartum depression articles, the placebo group averaged about 14 while the brexanolone groups averaged at 9 or A person with a score of 7 or below is considered to be virtually without depressive symptoms, postpartum depression articles.

About twice as many women on brexanolone achieved that status, Dr, postpartum depression articles. Meltzer-Brody said. After a month, more brexanolone patients managed to keep depressive symptoms at bay, compared to those who received placebos.

But in a study of moderately depressed women, those receiving placebos reported feeling as good as the brexanolone patients after 30 days. That may mean that standard antidepressants finally began kicking in, Dr. Spinelli said. Or perhaps the subjects simply improved on their own. Jonas said the experimental pill, given for two weeks in the clinical trials, seems to offer the same benefit as the infusion. It is being tested for treatment of major depression in addition to postpartum depression.

Pam Belluck is a health and science writer. She was one of seven Times staffers awarded the Pulitzer Prize for International Reporting for coverage of the Ebola epidemic.

Health F. Approves First Drug for Postpartum Depression. Here is what the group said and how you can use the information.


Postpartum depression: Symptoms, causes, and diagnosis


postpartum depression articles


Aug 23,  · Postpartum depression (PPD) affects one out of every eight women in the U.S. Read about postpartum depression symptoms, treatment, and causes. Statistics indicate that PPD can affect as many as 10% of new fathers, as well. Aug 14,  · Postpartum depression can begin anytime within the first year after childbirth. The cause is not known. Hormonal and physical changes after birth and the stress of caring for a new baby may play a role. Women who have had depression are at higher risk. If you think you have postpartum depression, tell your health care provider. Jun 22,  · Your articles about postpartum depression are a comprehensive, accurate account of the various ways that perinatal illnesses can present. Postpartum .